World Contraception Day 2022 is noticed on September 26 to unfold consciousness about contraceptive strategies. The aim of the day is to extend public understanding of contraception.
This marketing campaign goals to extend information of contraception choices so that girls and their companions could make an informed alternative about their reproductive well being.
What’s new in contraception?
The most recent and best in contraception consists of new nonhormonal intrauterine gadgets (IUDs) and male contraception, mentioned throughout a presentation on updates in contraception on the 2022 American School of Obstetricians and Gynecologists’ Annual Scientific & Scientific Assembly held in San Diego, California from Could 6-8.
This consists of Mirena (levonorgestrel-releasing intrauterine system; Bayer), which was authorized to forestall being pregnant for as much as 7 years by the FDA on August 11, 2021. Beforehand, Mirena was authorized to be used for as much as 6 years. The approval was primarily based on the Mirena Extension Trial, a multicenter examine investigating the efficacy of stopping being pregnant, in addition to treating heavy menstrual bleeding. Bayer plans on searching for approval to be used for up 8 years.
One other IUD that was not too long ago given approval for prolonged use is Liletta (levonorgestrel-releasing intrauterine system; AbbVie and Medicines360), which is now authorized for as much as 6 years and is predicted to see a 7-year approval comparatively quickly. (https://www.contemporaryobgyn.internet/)
Newest in contraception:
Phexxi (lactic acid, citric acid, potassium bicarbonate; Evofem Biosciences), a vaginal pH modulator gel that’s used inside an hour earlier than intercourse. Typically insurance coverage will cowl it, however sometimes it prices $300 per 12-count field, equalizing out to roughly $25 per syringe. Moreover, Phexxi demonstrated 86% efficacy with typical use.
Nextstellis (drospirenone and estetrol tablets; Mayne Pharma) is one other newly obtainable contraceptive that was authorized in April 2021. Drospirenone and estetrol is a brand new kind of estrogen that’s being labeled as a local estrogen with selective motion in tissues, or NEST.
Among the “game-changing” qualities of Nextstellis embody a half-life of 28 hours, a discount of affect on hemostasis parameters, and a minimal first-pass metabolism. Additionally it is at the moment being studied for a number of makes use of in reproductive well being together with hormone alternative remedy and menopause. Nevertheless, Nextstellis does have a black field warning for people who smoke over the age of 35 for elevated threat of cardiovascular occasions.
Subsequent, Annovera (segesterone acetate and ethinyl estradiol vaginal system; TherapeuticsMD) was authorized by the FDA in 2018. Sufferers will use the identical ring each month for a yr, leaving the ring in for 3 weeks after which leaving it out for 1 week, this can be repeated for 13 cycles. The advantages of utilizing Annovera are that it doesn’t require refrigeration, the ring is thicker than the present ring in the marketplace, and research demonstrated 97.3% efficacy in stopping being pregnant.
Slynd (drospirenone; Exeltis) is a progestin-only capsule authorized by the FDA in 2019. It really works by suppressing ovulation, whereas the present norethindrone capsule works by thickening cervical mucus. This capsule is a 24/4 routine of drospirenone 4 mg/placebo with a half-life of 30 hours and in trials confirmed to be a longer-acting progestin than norethindrone. Morrell additionally talked about a examine that evaluated girls lacking the capsule and located that even with a number of intentional 24-hour delays in pill consumption, ovulation suppression was nonetheless maintained.
Twirla (levonorgestrel and ethinyl estradiol transdermal system; Agile Therapeutics) is a patch that was authorized by the FDA in February 2022. It has the identical schedule as the present patch in the marketplace (1 patch per week for 3 weeks, after which 1 week with out). Nevertheless, it incorporates a decrease every day quantity of launched estrogen than the present patch (30 mcg vs 35 mcg).
About Male Contraception
There may be an rising marketplace for male contraception. Two are at the moment being studied: a gel and a capsule.
The gel consists of progesterone and testosterone, it’s rubbed onto the chest or shoulders every day. It really works by turning off sperm manufacturing with progesterone and makes use of testosterone to counterbalance the lack of libido related to progesterone.
A non-hormonal capsule can be being studied in mice. In these trials, male mice got the capsule orally for 4 weeks. The capsule works by concentrating on the protein retinoic acid receptor alpha (RAR-α). The examine demonstrated a drastic discount in sperm depend within the male mice and was 99% efficient in stopping being pregnant with no observable unwanted effects. Moreover, after receiving the compound, the mice might father pups inside 4-6 weeks. The examine authors anticipate human trials to start out in 2022.
Disclaimer
The Content material will not be meant to be an alternative to skilled medical recommendation, prognosis, or remedy. At all times search the recommendation of your doctor or different certified well being supplier with any questions you might have relating to a medical situation.
