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Extra Knowledge on the Reproductive Security of Lurasidone and Quetiapine

Redaktion by Redaktion
26. April 2023
in Women's Health
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Extra Knowledge on the Reproductive Security of Lurasidone and Quetiapine
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The Nationwide Being pregnant Registry for Atypical Antipsychotics was created with a view to consider the security of atypical antipsychotic medicines taken by girls throughout being pregnant. Since its inception, we now have enrolled over 3000 girls within the registry, and we now have been capable of publish information on the reproductive security of aripiprazole (Abilify), olanzapine (Zyprexa) and quetiapine (Seroquel). Now we now have some preliminary information on using lurasidone (Latuda) throughout being pregnant.

The Nationwide Being pregnant Registry for Atypical Antipsychotics is a potential pharmacovigilance program during which pregnant girls between the ages of 18 and 45 are enrolled and interviewed throughout being pregnant. Medical data are reviewed to substantiate the presence or absence of main malformations. 

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 Of the two,293 girls enrolled on the time of research, there have been 134 within the lurasidone publicity group, 264 within the quetiapine publicity group, and 886 controls. The chance of main malformations was 2.19% within the lurasidone group, 1.85% within the quetiapine group, and 1.77% within the controls. Odds ratios evaluating lurasidone and quetiapine with controls had been 1.24 (95% confidence interval [CI] = 0.36-4.32) and 1.04 (95% CI = 0.38-2.85), respectively. No particular patterns of malformations had been noticed in infants uncovered to the medicines. 

Reassuring Knowledge However Extra Knowledge on Lurasidone is Wanted

The newer atypical or second-generation antipsychotic brokers are used to deal with a spectrum of psychiatric problems, together with psychotic problems, bipolar dysfunction, main despair, PTSD and different nervousness problems. Our information on the reproductive security of those newer atypical brokers is rising. 

This examine supplies reassuring information concerning the security of prenatal publicity to lurasidone and quetiapine in a pattern of well-characterized members adopted prospectively and is in keeping with earlier research assessing infants uncovered to this class of medicines. Based mostly on the findings of this examine, it seems that lurasidone and quetiapine don’t look like main teratogens. No research to this point have demonstrated a rise in danger of malformations in youngsters uncovered to atypical antipsychotics.

Whereas the preliminary information from this examine is reassuring, bigger numbers of members are wanted to supply extra full information concerning the reproductive security of atypical antipsychotics as a category of medicines. These findings, taken along with different research, recommend that prenatal publicity to atypical antipsychotics doesn’t seem to considerably enhance the danger for congenital malformations, though we now have only a few documented exposures to among the latest atypicals, together with lurasidone (Latuda), iloperidone (Fanapt), brexpiprazole (Rexulti), and cariprazine (Vraylar).

The Nationwide Being pregnant Registry for Atypical Antipsychotics continues to recruit pregnant girls taking atypical antipsychotic medicines. CALL TOLL-FREE to study extra 1-866-961-2388 or fill out this Affected person Curiosity Kind to be contacted by our analysis coordinator. All info is saved strictly confidential. Participation consists of three cellphone interviews.

Ruta Nonacs, MD PhD

Cohen LS, Church TR, Freeman MP, Gaccione P, Caplin PS, Kobylski LA, Arakelian M, Rossa ET, Chitayat D, Hernández-Díaz S, Viguera AC.   Reproductive Security of Lurasidone and Quetiapine: Replace from the Nationwide Being pregnant Registry for Psychiatric Medicines.  J Womens Well being (Larchmt). 2023 Jan 30.

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