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A new paper within the Journal of Sports activities Sciences, in organising what seems to be a extremely uncommon and attention-grabbing experiment, casually drops this little fact-bomb in its opening sentence: “The cardiac phenotype of a considerable fraction of the inhabitants, i.e., mature ladies, is principally unresponsive to endurance coaching.”
Wow. The hearts of mature ladies are “primarily unresponsive”?! That looks as if form of a giant deal, for the reason that health-promoting results of endurance coaching are an article of religion on this column. So it’s price beginning out by acknowledging the power underrepresentation of ladies in train science research. Precisely how ladies reply to a given coaching program, and the way that adjustments with age, stays unsure as a result of it hasn’t been studied sufficient.
In truth, there’s some historical past to this declare. Again in 2019, two of the authors of the brand new examine, Candela Diaz-Canestro and David Montero of the College of Calgary, revealed a meta-analysis wanting on the extent to which women and men can elevate their VO2 max, a key marker of cardio health, by way of endurance coaching. Their conclusion: for a given dose of endurance coaching, males acquired a much bigger VO2 max enhance than ladies by about 2 ml/min/kg—a distinction that corresponds to a 7 to 9 % discount in untimely demise.
Following that examine, a gaggle of researchers from the Mayo Clinic wrote a letter to the editor of the journal suggesting that the distinction was primarily current in older ladies, not all ladies. Diaz-Canestro and Montero didn’t agree, however in 2020 they revealed one other meta-analysis, focusing this time on how the construction and performance of the center adjustments in response to endurance coaching. As soon as once more, they noticed greater diversifications in males than ladies—however this time, they did see proof that the distinction confirmed up primarily in older ladies. One thing, maybe associated to the hormonal adjustments that accompany menopause, appears to change how ladies reply to coaching later in life.
That’s the background that units up the brand new examine, from Diaz-Canestro, Montero, and Christoph Siebenmann. Their objective is to determine a solution to allow postmenopausal ladies to reap the complete advantages of endurance coaching—and their suggestion is to donate blood. A typical blood donation takes about 10 % of your blood, or 500 milliliters. That is just about the other of altitude coaching: you lose 10 % of your oxygen-carrying purple blood cells, and consequently your cardio health drops instantly. However the extra stress in your coronary heart, together with vigorous endurance coaching, may present the stimulus wanted to enhance health even in postmenopausal ladies.
If you withdraw 500 mL of blood, about 60 % of it’s plasma, and 40 % is purple blood cells. The plasma, which is the liquid a part of the blood, is straightforward to revive. Inside 24 to 48 hours of a blood donation, you’ll have added sufficient plasma to convey your complete blood quantity just about again as much as regular. However now your blood is diluted, as a result of there are nonetheless fewer purple blood cells to hold oxygen in any given quantity of blood pumped by your coronary heart. In ladies, purple blood cells could not return to regular for 9 to 12 weeks. Throughout that point, your coronary heart must pump a bit of tougher to produce oxygen for a given degree of exertion—and maybe, in consequence, it’s going to get correspondingly stronger.
For the examine, 15 reasonably lively ladies between the ages of 52 and 75, all postmenopausal, agreed to have 10 % or their blood quantity eliminated. Then, after three weeks to permit partial restoration of blood values, they accomplished an eight-week endurance coaching protocol that concerned two to 5 interval classes per week on a stationary bike.
Right here’s what the oxygen use (VO2) seemed like at completely different coronary heart charges. For every train depth, the white bar exhibits the baseline worth, the striped bar exhibits instantly after the blood withdrawal, and the black bar exhibits after eight weeks of coaching:

You’ll be able to see there’s a constant sample: the quantity of oxygen consumed at a given coronary heart price drops after blood withdrawal, then will increase to a higher-than-baseline worth after coaching. The rise from baseline is simply vital at 80 and 90 % coronary heart charges, so we are able to’t say that this protocol will increase VO2 max, however the information is actually suggestive of a attainable impact. Measurements of coronary heart construction and performance—the outcomes that, within the researchers’ earlier meta-analysis, didn’t reply to coaching in older ladies—additionally confirmed enchancment in some however not all circumstances.
So is that this a very good cause to hurry out and donate blood? Endurance athletes are famously (and justifiably) reluctant to half with their hard-earned hemoglobin. The concept, relatively than trashing your coaching, a well-time blood donation would possibly really offer you an additional coaching stimulus is attention-grabbing. If this analysis tempts you into donating a number of weeks earlier than the beginning of your subsequent huge coaching build-up, that looks as if a win-win state of affairs for you and for society.
As for the speculation that blood donation will overcome the decreased coaching response in older ladies, there are a bunch of caveats to contemplate. First, there was no management group that did the identical coaching with out donating blood. The authors emphasize that different research with comparable coaching protocols in comparable populations haven’t produced huge adjustments like this, which means that it’s the blood donation that sparked the magic. However nonetheless, with no direct comparability, how can we all know that this specific program of intervals wasn’t merely higher than the coaching utilized in earlier research?
Extra typically, it’s laborious to interpret the nuances of coronary heart diversifications. To be convincing, you need to know {that a} protocol helps ladies keep more healthy or dwell longer, not that, say, it subtly adjustments the size of 1 chamber of the center. That, because the researchers acknowledge, will take extra and longer-term analysis.
Nonetheless, whether or not or not their proposed reply is right, the query posed by these researchers is a vital one. These of us who dispense train recommendation are inclined to glibly assume that train is a common prescription that advantages everybody equally. If some teams akin to postmenopausal ladies don’t profit as a lot from the standard recommendation—and that’s nonetheless a giant if that deserves extra examine—then we have to discover various approaches.
For extra Sweat Science, be part of me on Twitter and Fb, join the e-mail e-newsletter, and take a look at my ebook Endure: Thoughts, Physique, and the Curiously Elastic Limits of Human Efficiency.
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